Immunologically released mediators in guinea pig allergic conjunctivitis
نویسندگان
چکیده
منابع مشابه
[Immunosuppressive effect of cholera toxin B on allergic conjunctivitis model in the guinea pig].
PURPOSE To investigate the immunosuppressive effects of mucosal immune therapy in experimental allergic conjunctivitis. METHOD We used 11 white Hartrey guinea pigs divided into two groups. Six animals (treated group) received pretreatment with topical instillation of cholera toxin B (4 micrograms/30 ml) and ovalbumin (10 micrograms/30 ml). The other group of 5 animals served as control. All t...
متن کاملSevere allergic reactions to guinea pig
BACKGROUND Allergic sensitization and reactions to guinea pig (Cavia porcellus) have been well documented in laboratory animal handlers, primarily manifesting as rhinitis, conjunctivitis, and asthma. Severe allergic reactions, however, are rare. METHODS We report two patients with severe allergic reactions following non-occupational exposure to guinea pigs. The first patient, an 11-year-old f...
متن کامل[Allergic mediators in tear from children with seasonal and perennial allergic conjunctivitis].
PURPOSE To evaluate the concentration of allergic mediators in tears of children with seasonal allergic conjunctivitis (SAC) and perennial allergic conjunctivitis (PAC) compared with controls. METHODS Twenty children with allergic conjunctivitis (17 SAC, and 3 PAC) and sixteen healthy children were included in this study. Tear samples were collected using a Merocel sponge (Oasis, 0525), and i...
متن کاملPlatelet-activating factor: an inflammatory mediator in the acute phase of allergic conjunctivitis in a guinea-pig model
The role of platelet-activating factor (PAF) as a mediator of increased conjunctival vascular permeability was investigated in a guinea-pig model of immediate hypersensitivity. Vascular permeability of the conjunctiva was determined by measuring the albumin content in lavage fluid (LF) after topical challenge with either PAF or ovalbumin. PAF produced a dose-dependent increase of the vascular p...
متن کاملMediators in anaphylaxis of guinea-pig small intestine.
With the use of a nonsensitized segment serving as indicator, the release of histamine or other substances during anaphylactic contraction in the isolated sensitized guinea-pig ileum was demonstrated (1). Histamine release in anaphylaxis was measured by immersing sensitized guinea-pig tissues including the small intestine in Tyrode solution containing the antigen (2,3). Attempts to demonstrate ...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1992
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)48854-9